@article{Arab2010PostpartumHI, title={Postpartum hemorrhage in a Jehovah's Witness patient controlled with Tisseel, tranexamic acid, and recombinant factor VIIa. Would you like email updates of new search results? Both the child's parents are Jehovah's Witnesses and refuse to give permission for a blood transfusion, re. Federal government websites often end in .gov or .mil. Primary Immune Thrombocytopenia: Novel Insights into Pathophysiology and Disease Management. strings of text saved by a browser on the user's device. We compared them with the non-JW patients in the registry. Clipboard, Search History, and several other advanced features are temporarily unavailable. 8600 Rockville Pike Abstract Introduction: The Australian and New Zealand Haemostasis Registry (ANZHR) included patients who received off-licence recombinant activated factor VII (rFVIIa) for critical bleeding from 2000 to 2009. The site is secure. 2007 Nov;25(9):1085.e1-2.doi: 10.1016/j.ajem.2007.03.007. 3 the core jehovah's witness beliefs 35 are as follows: (i) christ's second coming and armageddon are imminent and involve god restoring humans and the earth to the perfection of eden; (ii) a righteous 144 000 will be resurrected to a royal Dunkley S, Phillips L, McCall P, Brereton J, Lindeman R, Jankelowitz G, Cameron P. Ann Thorac Surg. One patient died intraoperatively from acute primary graft nonfunction, and the other died 38 hours postoperatively from severe anemia. Live donor liver transplantation without blood products: strategies developed for Jehovah's Witnesses offer broad application. MeSH Preanesthetic Assessment of the Jehovah's Witness Patient. ), or their login data. The subject population included nine males and one female with an average age of 50 years. Biol. J Trauma. He recovered completely without any adverse effects or neurological sequelae. ATryn ATryn is a lyophilized recombinant antithrombin III concentrate. Six patients underwent cadaveric and four live donor liver transplantation. Perm J. 1998 Mar;9 Suppl 1:S93-5. NovoSeven is the brand name for recombinant factor VIIa. 7.9 U. Martinowitz, M. Michaelson. Curr Opin Organ Transplant. Disclaimer, National Library of Medicine Conclusion La prise en charge optimale d'une patiente refusant l'administration de produits sanguins ncessite une approche multidisciplinaire, ainsi qu'une combinaison de traitements traditionnels et novateurs. 2005 Aug;18(8):929-36. doi: 10.1111/j.1432-2277.2005.00160.x. Blood-Borne Pathogens. Fetofetal Transfusion Blood Loss, Surgical Blood Group Incompatibility Anemia, Neonatal Anemia Erythroblastosis, Fetal Postoperative Hemorrhage Fetomaternal Transfusion Thrombocytopenia Rh Isoimmunization Anemia, Sickle Cell Hemorrhage beta-Thalassemia Blood Coagulation Disorders Iron Overload Postoperative Complications Exsanguination Acute Lung Injury . Before Introduction Recombinant activated factor VII (rFVIIa) (NovoSeven R; Novo Nordisk A/S, Bagsvaerd, Denmark) is a haemostatic agent first developed for bleeding associated with haemophilia and trauma, but for which the indications continue to expand. Successful treatment of intestinal hemorrhage in a Jehovah's Witness patient. Approximately 1.3% of the ANZHR patients were Jehovah's Witnesses (JWs). official website and that any information you provide is encrypted PMC The contemporary approach to the care of Jehovah's witnesses. Surgeries were conducted following our established protocol for transfusion-free liver transplantation, which includes preoperative blood augmentation, intraoperative blood salvage, acute normovolemic hemodilution, and postoperative blood conservation. Recombinant factor VIIa for major obstetric haemorrhage in a Jehovah's Witness Authors: Richard Laird Queen's University Belfast U Carabine No full-text available . One of the most spectacular advancements in the control of PPH has been the use of recombinant activated factor VII (rFVIIa) (NovoSeven ; Novo Nordisk A/S, Bagsvaerd, Denmark). government site. government site. The .gov means its official. The .gov means its official. Before The https:// ensures that you are connecting to the 2005 Aug;79(4):344-5. doi: 10.1002/ajh.20345. Clipboard, Search History, and several other advanced features are temporarily unavailable. VA class: BL500. Other case reports. Recombinant Human Coagulation Factor VIIa in Jehovah's Witness Patients Undergoing Liver Transplantation - Nicolas Jabbour, Singh Gagandeep, Peilin Alice Cheng, Brendan Boland, Rod Mateo, Yuri Genyk, Rick Selby, Gary Zeger, 2005 A total of 42 JW and 3134 non-JW patients were included in the analysis. Indian J Anaesth. Purpose To present a case of survival of a cognitively intact Jehovah's Witness patient with an aortic dissection who underwent hypothermic arrest. J. Obstet. Coagulopathy after cardiopulmonary bypass in Jehovah's Witness patients: management of two cases using fractionated components and factor VIIa. PMC J Trauma. HHS Vulnerability Disclosure, Help We compared them with the non-JW patients in the registry. }, author={Albert Hsieh and Izham Cheong}, journal={The American journal of emergency medicine}, year={2007}, volume={25 9}, pages={ 1085.e1-2 } } sharing sensitive information, make sure youre on a federal The cost of recombinant FVIIa was 10 250 but, although the final outcome in this patient was unsuccessful, recombinant factor VIIa clearly arrested bleeding in the face of life-threatening haemorrhage and coagulopathy and would be of value again in similar circumstances. Please enable it to take advantage of the complete set of features! and transmitted securely. Australian and New Zealand Haemostasis Registry Steering Committee. MeSH 2006 Feb;83(2):126-38. doi: 10.1532/IJH97.E0517. Before Bookshelf MeSH The .gov means its official. [Percutaneous nephrolithotripsy supported by recombinant factor VIII in a patient with hemophilia A, a Jehovah's Witness]. Unable to load your collection due to an error, Unable to load your delegates due to an error. Bookshelf Management of patients who refuse blood transfusion. Pharmacotherapy. Hepatogastroenterology. The https:// ensures that you are connecting to the Bethesda, MD 20894, Web Policies By using the Infona portal the user accepts automatic saving and using this . 2010 Nov;19(11):655-9. doi: 10.1016/j.hlc.2010.07.010. In patients with haemophilia who do not have the disease, this recombinant factor VIIa can be used for the prevention and treatment of bleeding. official website and that any information you provide is encrypted Approximately 1.3% of the ANZHR patients were Jehovah's Witnesses (JWs). Long-term management of chronic immune thrombocytopenic purpura in adults. and transmitted securely. This presents a clinical challenge when caring for Jehovah's Witness (JW) patients who refuse transfusion of red cells, platelets, and fresh frozen plasma. Recombinant human erythropoietin therapy in critically ill Jehovah's Witnesses. FOIA Abstract Introduction: The Australian and New Zealand Haemostasis Registry (ANZHR) included patients who received off-licence recombinant activated factor VII (rFVIIa) for critical bleeding. Antifibrinolytics, desmopressin, and recombinant activated factor VII (rFVIIa) have all been administered to successfully treat CPB-induced coagulopathy in these patients . This site needs JavaScript to work properly. A Jehovah's Witness with severe haemophilia A and a high titre, high responding inhibitor to both human and porcine factor VIII (FVIII) was treated with recombinant activated factor VII (rVIIa) during an episode of intracranial bleeding. Use of recombinant activated factor VII in Jehovah's Witness patients with critical bleeding. 2011 Jun;16(3):326-30. doi: 10.1097/MOT.0b013e328346dd36. Unable to load your collection due to an error, Unable to load your delegates due to an error. excessive bleeding (> 2 l) after cardiac surgery is encountered in 5-7% of jehovah's witness patients, 1 and necessitates reexploration in 3.6% of cases. ANZ Journal of Surgery 2012 Royal Australasian College of Surgeons. Clipboard, Search History, and several other advanced features are temporarily unavailable. Factor rFVIIa was used at a dose of 80 microg/kg intravenously just prior to the incision in all patients, and a second intraoperative dose was used in 3 patients. It is administered intravenously (IV). [Successful treatment of hemothorax with recombinant factor VIIa in a hemophilic child with inhibitor]. 207 (2016) 56-61] Phillips LE, McLintock C, Pollock W, Gatt S, Popham P, Jankelowitz G, Ogle R, Cameron PA; Australian and New Zealand Haemostasis Registry. However . , Robin Braman, R.E.M.T. PMC Careers. 2010 Apr;59(4):297-311. doi: 10.1007/s00101-010-1701-2. HHS Vulnerability Disclosure, Help Bookshelf Hematol J. Jehovah's Witness 1. official website and that any information you provide is encrypted 2008 Apr;17(2):193-4. doi: 10.1016/j.ijoa.2007.09.013. It is not yet available in the United States. Disclaimer, National Library of Medicine official website and that any information you provide is encrypted Careers. During the remaining course of surgery, the body temperature dropped to 34.7C, and surgeons noticed oozing from the surgical wound. Careers. 2007 Apr;104(4):763-5. doi: 10.1213/01.ane.0000250913.45299.f3. This report suggests factor rFVIIa might have a much broader application in surgery in the control of bleeding associated with coagulopathy. 2008 Jul;65(1):237-47. doi: 10.1097/TA.0b013e318176cc66. Tokin C, Almeda J, Jain S, Kim J, Henderson R, Nadim M, Sher L, Selby RR. J Clin Med. Anesth Analg. Recombinant VIIa concentrate in the management of bleeding following prothrombin complex concentrate-related myocardial infarction in patients with haemophilia and inhibitors. Approximately 17% of the non-JW patients were hypothermic (T < 35C) and about 19% were acidotic (pH < 7.2) at the time of initial rFVIIa administration. sharing sensitive information, make sure youre on a federal This site needs JavaScript to work properly. 2008 Nov;28(11):1383-90. doi: 10.1592/phco.28.11.1383. Liver transplant in Jehovah's Witnesses patients. Recombinant activated factor VII (rFVIIa) (NovoSeven; Novo Nordisk A/S, Bagsvaerd, Denmark) is a haemostatic agent first developed for bleeding associ The use of recombinant factor viia in a jehovah's witness with auto-immune thrombocytopenia and post-splenectomy haemorrhage Br J Haematol. References Citing Literature Volume 119, Issue 1 October 2002 Pages 286-288 Pharmacology and clinical use of recombinant activated factor seven in neurosciences. Fishman PE, Drumheller BC, Dubon ME, Slesinger TL. Rimma Goldberg, Katharine J. Drummond. During total knee arthroplasty, the preoperative blood loss is reduced by adhesive of fibrin tissue. MeSH Jehovah's Witness; Recombinant activated factor VIII; Surgery; Warfarin; Access to Document. Treatment with rVIIa in this case was safe and effective. Methods: Request PDF | Recombinant Human Coagulation Factor VIIa in Jehovah's Witness Patients Undergoing Liver Transplantation | Indisputably, liver transplantation is among the most technically . Accessibility Epub 2010 Sep 1. The Australian and New Zealand Haemostasis Registry (ANZHR) included patients who received offlicence recombinant activated factor VII (rFVIIa) for critical bleeding from 2000 to 2009, and 1.3% of the ANZHR patients were Jehovah's Witnesses (JWs). Reprod. Recombinant human. rFVIIa was initially developed for the treatment of bleeding episodes in patients with hemophilia A or B with formation of alloantibodies to FVIII or FIX after . FOIA Int J Hematol. 2008 Jul;65(1):237-47. doi: 10.1097/TA.0b013e318176cc66. The contemporary approach to the care of Jehovah's witnesses. Proximal extension of the dissection necessitated prolonged . bleeding response (stopped/attenuated or unchanged) to rFVIIa, mortality) were compared between JW and non-JW patients using Fisher's exact chi-square tests and Kruskal-Wallis tests. The distribution of gender and contexts of critical bleeding in the two groups was significantly different. Recombinant activated factor VII in cardiac surgery: experience from the Australian and New Zealand Haemostasis Registry. Davis SM , Kaye AH J Clin Neurosci, (3):219-220 2005 MED: 15851068 Two of the six cadaveric recipients died. Please enable it to take advantage of the complete set of features! . We present in this paper 10 liver transplants in Jehovah's Witness patients using this novel product at University of Southern California-University Hospital. Written by ASHP. Comparison of outcome in Jehovah's Witness patients in cardiac surgery: an Australian experience. FOIA 2010 Oct 5;3:305-11. doi: 10.2147/IJGM.S4722. Please enable it to take advantage of the complete set of features! The proportion of positive responders to rFVIIa (stopped/attenuated bleeding following rFVIIa use) was similar in both groups (75% non-JWs, 74% JWs; P = 1.0). Liver transplantation in Jehovah's witnesses. . Abstract Introduction: The Australian and New Zealand Haemostasis Registry (ANZHR) included patients who received off-licence recombinant activated factor VII (rFVIIa) for critical bleeding from 2000 to 2009. 2004;5(3):281-2. doi: 10.1038/sj.thj.6200395. Unable to load your collection due to an error, Unable to load your delegates due to an error. This site needs JavaScript to work properly. . Safety, efficacy and cost-effectiveness of home therapy with recombinant activated factor VII in a patient with severe haemophilia A and an anti-factor VIII inhibitor. 2003 Sep-Oct;50(53):1697-9. Results: Transfusion free surgery: single institution experience of 27 consecutive liver transplants in Jehovah's Witnesses. Diseases 61. This therapeutic agent should be considered in haemophilia patients with inhibitors who refuse management with blood products on religious grounds and when recombinant factor VIII is not a cost-effective option. Recombinant activated factor VII (rFVIIa) (NovoSeven; Novo Nordisk A/S, Bagsvaerd, Denmark) is a haemostatic agent first developed for bleeding associ . Recombinant factor VIIa, but no blood products were administered. official website and that any information you provide is encrypted James Isbister. 8600 Rockville Pike Chemical name: Blood-coagulation factor VII (human clone HVII2463 protein moiety) Molecular formula: C 1982 H 3054 N 560 O 618 S 28. In patients that refuse any blood derived products, recombinant factor VIIa has successfully been used to augment the management of either upper or lower gastrointestinal bleeding [2] on a Anesthesiology. Careers. The site is secure. [Perioperative management of Jehovah's Witness patients. Severe gastrointestinal haemorrhage responding to recombinant factor VIIa in a Jehovah's Witness with refractory immune thrombocytopenia. Affiliations. Discussion: Would you like email updates of new search results? 2 recombinant factor viia (rfviia, novoseven; novo nordisk, princeton, nj), produced in baby hamster kidney cell lines and free of human protein, could be an alternative hemostatic agent and is 2004 Aug;240(2):350-7. doi: 10.1097/01.sla.0000133352.25163.fd. Several factors were observed to be significantly different between JW and non-JW patients, yet the proportions of responders to rFVIIa were similar in both groups. 4.1.7 Uncontrolled bleeding in Jehovah Witness patients in whom all surgical causes have been excluded, Yes No Section 2 . Disclaimer, National Library of Medicine 2012 The Authors. PMC Disclaimer, National Library of Medicine Approximately 28% of non-JW and 17% of JW patients were deceased by day 28 following rFVIIa use (P = 0.16). Authors Dominic P Waddington , Frank T McAuley , John P Hanley , Geoffrey P Summerfield PMID: 12358947 DOI: 10.1046/j.1365-2141.2002.381113.x The patient experienced no further blood loss following the administration of rFVIIa, and no adverse events were observed. ANZ Journal of Surgery, 2013. Introduction: The Australian and New Zealand Haemostasis Registry (ANZHR) included patients who received off-licence recombinant activated factor VII (rFVIIa) for critical bleeding from 2000 to 2009. Treatment of excessive bleeding in Jehovah's Witness patients after cardiac surgery with recombinant factor VIIa (NovoSeven). An official website of the United States government. "Re: Campbell S, Corcoran P, Manning E, Greene R, for the Irish Maternal Morbidity Advisory Group. The actual factors influencing response to rFVIIa are yet to be determined. FOIA Anaesthesist. A recombinant von Willebrand factor has been made and tested successfully in dogs with VWD. @article{Hsieh2007UseOR, title={Use of recombinant activated factor VII in a Jehovah's Witness patient. Accessibility 2009 Winter;13(1):18-28. doi: 10.7812/TPP/08-029. All living donor liver transplantation (LDLT) recipients did well and were discharged uneventfully with normal liver functions. The .gov means its official. Recombinant factor VIIa also known as eptacog alfa , and sold under the brand name NovoSeven among others, is a form of blood factor VII that has been manufactured via recombinant technology. L'utilisation d'acide tranexamique, de facteur recombinant VIIa et de Tisseel a jou un rle important dans la jugulation de l'hmorragie. We compared them with the non-JW patients in the registry. Download Download PDF. Drug class: Hemostatics. 2008 Oct;25(10):625-30. doi: 10.1136/emj.2007.057158. Recombinant factor VIIa (rFVIIa) (Novoseven, Novo Nordisk A/S, Baagsvaerd, Denmark) is the activated form of factor VII produced from factor VII cDNA transfected into hamster kidneys. Jehovah's Witnesses' blood fractions are decided by each member of the group. The site is secure. An official website of the United States government. We report a warfarin-anticoagulated Jehovah's Witness patient with an acute subdural haematoma for whom rFVIIa was used perioperatively.
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